Sr Associate, Process Development Upstream

Location: 

San Diego, CA, US, 92121


 

Those who join Emergent BioSolutions feel a sense of ownership about their future. You will excel in an environment characterized by respect, innovation and growth opportunities. Here, you will join passionate professionals who advance their scientific, technical and professional skills to develop products designed-to protect life.

JOB SUMMARY 

This position is focused on upstream process development to assist developing and optimizing cell culture process including media development, feeding strategies, process parameter optimization, process characterization and scale-up for large scale production to support vaccine or monoclonal antibody development from preclinical through Phase III, to commercialization. 

The main responsibilities will include assisting the design, execution, and documentation of experiments to develop phase-appropriate upstream processes (bioreactor, transfection, infection, microfiltration, filtration) to enable transfer and scale-up of robust processes to the commercial space.

Documentation of these activities is also required, including recording in lab notebooks, draft SOPs and batch records, writing development reports. The successful candidate will be able to work in a fast-paced team environment and be able to learn new skills quickly.


ESSENTIAL FUNCTIONS
Reasonable accommodations will be made to enable individuals with disabilities to perform the essential functions.

•    Perform adherent and suspension mammalian cell culture using disposable technologies. 
•    Perform mammalian cell cultures in multi well plates, shake flasks, CellSTACKs and bioreactors. Prepare media and monitor cell density, viability, etc.
•    Develop and optimize the cell culture parameters (for various cell lines) and nutrient requirement in shaker flasks and disposable bioreactors (10L, 50L and 200L) for mammalian suspension cell growth for virus or virus like particle, or antibody production.
•    Write technical reports and tech transfer reports, draft SOPs and batch records.
•    Utilize and maintain related equipment for such operations as bioreactors, pumps, mixer, tube welders, ect.
•    Troubleshooting the issues related to cell culture process development.
•    Work with vendors or CRO’s to evaluate materials, equipment and to review development reports. 
•    Work with a high degree of independence to lead R&D projects and contribute to project planning.
•    Maintain high level of scientific expertise through familiarity with current scientific literature.

The above statements are intended to describe the nature of work performed by those in this job and are not an exhaustive list of all duties. Nothing in this job description restricts managements right to assign or reassign duties and responsibilities to this job at any time which reflects management’s assignment of essential functions. 

MINIMUM EDUCATION, EXPERIENCE, SKILLS
•    B.S. degree in biology or related area with 3-6 years of experience working in process development or protein science required.  
•    Cell culture experience, cell transfection experience and strong aseptic technique.
•    Mammalian cell culture experience with various adherent cells and suspension cells such as Vero, HEK293, CHO cells preferred.
•    Experience working with bioreactors (small scale and large scale), both rocker and/or stir tank preferred.
•    Team player and collaborator, ability to listen and communicate in a clear and timely manner
•    Proven collaboration skills, learning agility, conceptual and strategic thinking, passion for results, and ability to navigate ambiguity.
•    Design of Experiment (DoE) is a plus
•    GMP experiences is a plus
 

 

Successful applicants for this position that are required to be onsite at any Emergent site at any time, must be fully vaccinated against COVID-19 as a condition of employment,  subject to legally required exemptions.

There are physical/mental demands and work environment characteristics that must be met by an individual to successfully perform the essential functions of the job. This information is available upon request from the candidate.

Reasonable accommodations may be made to enable individuals with disabilities to perform all essential functions.
 

Emergent BioSolutions is an Equal Opportunity/Affirmative Action Employer and values the diversity of our workforce.  Emergent does not discriminate on the basis of race, color, creed, religion, sex or gender (including pregnancy, childbirth, and related medical conditions), gender identity or gender expression (including transgender status), sexual orientation, age, national origin, ancestry, citizenship status, marital status, physical or mental disability, military service or veteran status, genetic information or any other characteristics protected by applicable federal, state or local law.
 

Information submitted will be used by Emergent BioSolutions for activities related to your prospective employment. Emergent BioSolutions respects your privacy and any use of the information submitted will be subject to the terms of our Privacy Policy .
 

Emergent BioSolutions does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Emergent BioSolutions’ approved agency list. Unsolicited resumes or candidate information submitted to Emergent BioSolutions by search/recruiting agencies not already on Emergent BioSolutions’ approved agency list shall become the property of Emergent BioSolutions and if the candidate is subsequently hired by Emergent BioSolutions, Emergent BioSolutions shall not owe any fee to the submitting agency.

ABOUT EMERGENT

Protecting and Enhancing 1 billion lives by 2030 focuses our energy to improve the quality of life for individuals around the world, giving them the opportunity to experience the fullness of life.

Our drive towards this vision informs all of our actions—whether it is our approach to product development, manufacturing, encouraging employee health and wellness or giving back to the community—we strive every day to achieve this shared goal.

WE BELIEVE IN OUR VALUES

  • Stand shoulder to shoulder no matter what
    • We combine our best thinking and communicate openly to support each other.
  • Break through thinking
    • We take smart risks, pursue innovation and challenge ourselves to constantly improve.
  • Own it always
    • Every person at Emergent is engaged and accountable for delivering on our commitments.
  • Compete where it counts
    • We set the right goals and respect each other as we conquer them together.


Nearest Major Market: San Diego