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Sr Scientist, Upstream Process Development

Location: 

San Diego, CA, US, 92121


 

Those who join Emergent BioSolutions feel a sense of ownership about their future. You will excel in an environment characterized by respect, innovation and growth opportunities. Here, you will join passionate professionals who advance their scientific, technical and professional skills to develop products designed-to protect life.

This position is focused on upstream process development and work as SME to lead the efforts for developing and optimizing cell culture process including media development, feeding strategies, process parameters optimization, process characterization and scale-up for large scale production to support vaccine or monoclonal antibody development from preclinical through Phase III, and commercialization. The main responsibilities will include the design, execution, and documentation of experiments to develop phase-appropriate upstream processes (bioreactor, transfection, infection, microfiltration, filtration) for clinical supply production, and further optimize/scale up these processes to enable transfer of robust processes to the commercial space. 


ESSENTIAL FUNCTIONS
Reasonable accommodations will be made to enable individuals with disabilities to perform the essential functions.

•    Provide leadership and technical direction for development and execution of sound upstream processes for variety of vaccine or Mab candidates.
•    Function as project technical leader and provide update and presentation in meetings.
•    Develop and optimize the cell culture parameters (for various cell lines) and nutrient requirement in shaker flasks and disposable bioreactors (10L, 50L and 200L) for mammalian suspension cell growth for virus or virus like particle, or antibody production.
•    Develop and optimize the transient transfection, viral infection process or stable cell line production process to maximize the yield.
•    Use DOE software to design the experiment, analyze the results for the product yield improvement.
•    Author and review technical document and reports, support IND CMC writings and BLA filings.
•    Analyze data and interpret results. Present and discuss results of experiments with the department and project teams.  
•    Participate on cross-functional project teams and coordinate intradepartmental research efforts.
•    Train, mentor, and supervise junior level scientists and associates.
•    Work with a high degree of independence to lead R&D projects and contribute to project planning.
•    Maintain high level of scientific expertise through familiarity with current scientific literature.

The above statements are intended to describe the nature of work performed by those in this job and are not an exhaustive list of all duties. Nothing in this job description restricts managements right to assign or reassign duties and responsibilities to this job at any time which reflects management’s assignment of essential functions. 

 

MINIMUM EDUCATION, EXPERIENCE, SKILLS
•    Degree in biology, bioengineering, chemical/biochemical engineering or a related field. PhD with minimal 4 years' relevant experience, or M.S. with 8 years or B.S. with 10 years relevant experiences.
•    Minimum of 5 years direct experience in mammalian cell culture. Good aseptic technique is a must.
•    Mammalian cell culture experience with various adherent cells and suspention cells such as Vero, HEK293, CHO cells is required. 
•    Prior experiences with transient transfection and viral infection are preferred. 
•    Design of Experiment (DoE) experience is necessary. Excellent understanding of scientific methods and statistical analysis is required.
•    Bioreactor (small scale and large scale) experience is required.
•    Experience with Ambr 250 system is a plus.
•    Experiences with late phase process development are preferred.
•    Engineering knowledge/hands on experience with equipment troubleshooting is preferred. 
•    Knowledge and experience with operating in regulated GCLP laboratory environments is required, cGMP experience is plus.
•    Ability to analyze complex data and reach valid scientific conclusions.
•    Excellent organization skills, supervisory experience, and excellent writing and presentation skills are required.
•    Capable of searching scientific literature to gain information about specific topics.
•    Plan project tasks effectively, prioritize, keep to timeline, and multi-task.
•    Proven collaboration skills, learning agility, conceptual and strategic thinking, passion for results, and ability to navigate ambiguity.
 

 

Successful applicants for this position must be fully vaccinated against COVID-19 as a condition of employment. Individuals with qualifying medical issues or sincerely held religious beliefs or practices that may prevent them from getting the vaccine may request an exemption from the vaccine requirement.

There are physical/mental demands and work environment characteristics that must be met by an individual to successfully perform the essential functions of the job. This information is available upon request from the candidate.

Reasonable accommodations may be made to enable individuals with disabilities to perform all essential functions.
 

Emergent BioSolutions is an Equal Opportunity/Affirmative Action Employer and values the diversity of our workforce.  Emergent does not discriminate on the basis of race, color, creed, religion, sex or gender (including pregnancy, childbirth, and related medical conditions), gender identity or gender expression (including transgender status), sexual orientation, age, national origin, ancestry, citizenship status, marital status, physical or mental disability, military service or veteran status, genetic information or any other characteristics protected by applicable federal, state or local law.
 

Information submitted will be used by Emergent BioSolutions for activities related to your prospective employment. Emergent BioSolutions respects your privacy and any use of the information submitted will be subject to the terms of our Privacy Policy .
 

Emergent BioSolutions does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on Emergent BioSolutions’ approved agency list. Unsolicited resumes or candidate information submitted to Emergent BioSolutions by search/recruiting agencies not already on Emergent BioSolutions’ approved agency list shall become the property of Emergent BioSolutions and if the candidate is subsequently hired by Emergent BioSolutions, Emergent BioSolutions shall not owe any fee to the submitting agency.

ABOUT EMERGENT

Protecting and Enhancing 1 billion lives by 2030 focuses our energy to improve the quality of life for individuals around the world, giving them the opportunity to experience the fullness of life.

Our drive towards this vision informs all of our actions—whether it is our approach to product development, manufacturing, encouraging employee health and wellness or giving back to the community—we strive every day to achieve this shared goal.

WE BELIEVE IN OUR VALUES

  • Stand shoulder to shoulder no matter what
    • We combine our best thinking and communicate openly to support each other.
  • Break through thinking
    • We take smart risks, pursue innovation and challenge ourselves to constantly improve.
  • Own it always
    • Every person at Emergent is engaged and accountable for delivering on our commitments.
  • Compete where it counts
    • We set the right goals and respect each other as we conquer them together.


Nearest Major Market: San Diego